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DoxyPEP: The STI "Morning After Pill"

by Alexa Styliadis

antibiotics for STI prevention

DoxyPEP is an antibiotic that you can take after sex to prevent a sexually transmitted infection (STI).

stop STIs before they occur

DoxyPEP is a post-exposure preventative treatment for syphilis, chlamydia, and gonorrhea. Think of it as a morning-after pill for bacterial STIs.

When should I take DoxyPEP?
Ideally, you should take two 100 mg pills of doxycycline within 24 hours, but no later than 72 hours after condomless sex. Condomless sex means oral, anal, or vaginal/front-hole sex where a condom is not used for the entire time.

What if I have sex again?
If you have sex again within 24 hours of taking doxycycline, take another dose 24 hours after your last dose. Do not take more than 200 mg (two 100 mg pills) every 24 hours.

How should I take DoxyPEP?
Take doxycycline with plenty of water. If your stomach gets upset, try taking it with food.

  • Some people are more sensitive to the sun when they take doxycycline, so wear sunscreen.
  • Please do not share doxycycline with others.
  • Avoid dairy products, calcium, antacids, or multivitamins 2 hours before after taking doxycycline.

DoxyPEP does NOT help prevent:

  • HIV
  • Mpox (monkeypox)
  • Other viral infections

If you're interested in DoxyPEP, schedule a same-day appointment with a medical provider who specializes in sexual health (or pick the date that works for you)!


Take control of your sexual health. Call us at 585.545.7200 to schedule an appointment or click here to schedule an appointment online.